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Total Iron- Binding Capacity

Total Iron- Binding Capacity 
Synonyms - Specimen - Reference Value - Method - Description - Indication - Interpretation 

Synonyms : TIBC, Fe sat 
Specimen : Serum 
Reference Value : transferrin 200 - 380 mg/dL , Iron saturation 20 - 50 % c
METHOD
Spectrophotometry  for TIBC and nephelometry for transferrin 

DESCRIPTION 
Iron travels in the blood stream bound to transport proteins . Transferrin ( which is synthesized in the liver )is the major iron - transport protein , carrying 60 to 70 percent of the body's iron   .For this reasons ,total iron binding capacity (TIBC)And transferrin are sometimes referred to interchangeably. Unbound iron is highly toxic , but there is generally an excess of transferrin available to prevent the buildup of unbound iron in circulation . The percentage of iron saturation is calculated by dividing the serun iron value by the TIBC value and multiplying by 100 . Total iron capacity is calculated from transferr  levels measured  immunologically 

Indication
1 - Assist in the diagnosis of iron deficiency anemia                
2 - Differentiation between iron deficiency anemia and anemia secondary to chronic disease 
3 - Monitor hematologic response to therapy during pregnancy and iron deficiency anemias 
4 - Provide support for diagnostic of hemochromatosis or disorder of iron metabolism of iron metabolism and storage 


 Interpretation 
TIBC I increased  in 
1 - Acute liver disease 
2 - Hypochromic anemia 
3 - Late Pregnancy 
    
Decreased in 
Chronic infection 
Cirrhosis - Hemochromatosis 
Hemolytic anemia 
Protein depletion 
Renal disease 
Thalassemia - Sideroblastic anemia 

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