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Measurement of iron in blood

IRON 
Synonym - specimen - Refrence Value - Method - Description - Indications 


 Synonym          :          Fe 

Specimen            :          Serum 

Reference Value :      65 - 175 ug/d      
 Method            :     Spectrophotometry                             

Description 

Iron plays a principle role in erythropoiesis 
Irone is necessary for the proliferation and maturation of red blood cells and is required for hemoglobin synthesis .65 perecent of iron resides in hemoglobin and 3 percent in myoglobin .a small amount is also found in cellular enzymes that catalyze the oxidation and reduction of iron . The remainder of iron is stored in the liver , bone marrow , and spleen as ferritin  or hemosiderin .Any iron present in the serum  is in transit among the alimentary tract , the bone marrow , and available iron storage forms . Iron travels in blood stream bound to transferrin , a protein manufactured by the liver . Normally iron enters the body by oral ingestion , only 10% is absorbed , but 20% can be absorbed in patients with iron deficiency anemia . unbound iron is highly toxic 


Indications 
1 - Assists in diagnostic of blood loss , indicated by decreased serum iron 
2 - Assists in the diagnostic of hemochromatosis or other disorders of iron metabolism and storage 
3 - Determine the presence of disorders that involved defects in iron absorption 
4 - Determine the differential diagnosis of anemia 
5 - Evaluate accidental iron poisoning 
6 - Evaluate thalassemia  and sideroblastic anemia 
7 - Monitor hematologic responses during pregnancy 
8 - Monitor response to treatment for anemia 

Interpretation 
Iron  Increased in 
1 - Acute iron poisoning (childern)x
2 - Acute liver disease 
3 - Aplastic anemia 
4 - Excessive iron therapy 
5 - Hemochromatosis 
6 - Hemolytic anemias 
7 - Lead toxicity 
8 - pernicious anemia 
9 - Sideroblastic  anemia 
10 - Thalassemia 
11 - Drugs : estrogen , oral contraceptives 

Iron  Decreased in 
1 - Acute and chronic infection 
2 - Carcinoma 
3 - Chronic blood loss 
4 - Hypothyroidism 
5 - Iron-deficiency anemia 
6 - Chronic renal failure 
7 - postoperative states 
8 - Active hematopoiesis 
9 - Protein malnutrition 

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