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Bile acids

Bile acids

- Produced from cholestrol in the liver where they are conjugated with taurine and secreted into the bile and subsequently the intestines . They are then reabsorbed from  the ileum into the portal circulation where they are removed by the liver .

- Total serum bile acid levels may be measured by a very sensitive radio immunoassay . An enzymatic spectrophotometry method may be used .

- Overnight fast should be occurred , a pre sample of blood is taken , the patients are then fed a meal and 2 hrs later , a post sample of blood is drawn

- Highest increases in serum bile acids occure in conditions such as photosynthetic shunt , cirrhosis and extra hepatic cholestasis , due to an abnormal portal ciculation or reduced uptake by the liver .
Moderate increases are present in acute hepatitis or hepatic neoplasia , and slight increases may be found with steroid hepatopathy . 

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