Skip to main content

INTRODUCTION OF TUMOR MARKERS

 INTRODUCTION OF TUMOR MARKERS 

Cancer is a word used to describe a condition characterized by spreading destruction of any kind 
Cancer is the name given to a group or diseases associated with the development , growth  , and spread of destructive overgrowth of tissue , called Malignant tumor or neoplasm , in living organism 


A tumor is benign when it is restricted to its primary site and malignant when it is capable of invading surrounding tissue.

Malignant Tumors 

these are invasive , destruction and associated with a generally poor prognosis and high mortality rate 
Malignant tumors growth may occur at any site in the organism and may spread in time to other sites . 

Pathogenesis of the disease is largely due to 

a- Obstruction and destruction of other vital structures in the body 
b - Functional activity of a substance produced by the tumor .
c - Bleeding 
d - Infection 
e - Toxic substances associated with infarction and necrosis 

The  major difference between normal cells and tumor cells is that growth control has been lost in tumor cells . 

Neoplastic transformation is associated with altered gene expression , which may affect production of enzymes  , hormones , receptors , protein and metabolites that are released into the circulatory system .
These substances , if they can be measured and in the diagnosis and characterization of disease and have potential use in the treatments and cure of cancers . 
This group of substances has come to be known as Tumor markers .










Comments

Popular posts from this blog

MICROSCOPIC URINALYSIS

MICROSCOPIC URINALYSIS   Methodology A sample of well-mixed   urine (usually 10-15 ml) is centrifuged in a test tube at relatively low speed (about 2-3,000 rpm) for 5-10 minutes until a moderately cohesive button is produced at the bottom of the tube. The supernatant is decanted and a volume of 0.2 to 0.5 ml is left inside the tube. The sediment is resuspended in the remaining supernatant by flicking the bottom of the tube several times. A drop of resuspended sediment is poured onto a glass slide and coverslipped.

Liver Enzymes

Liver Enzymes   Definition A liver enzyme is a protein that helps to speed up a chemical reaction in the   liver. Liver function tests are blood tests that are used to evaluate various functions of the liver - for example, metabolism, storage, filtration and excretion, which are often performed by liver enzymes. However, not all liver function tests are measures of enzyme function. • ALT - (alanine aminotransferase )   - was previously called SGPT is more specific for liver damage. The ALT is an enzyme that is produced in the liver cells (hepatocytes) therefore it is more specific for liver disease than some of the other enzymes. It is generally increased in situations where there is damage to the liver cell membranes. All types of liver inflammation can cause raised ALT.    • AST - (aspartate aminotransferase) which was previously called SGOT. This is a mitochondrial enzyme that is also present in heart, muscle, kidney and brain therefore it is less specific

Stool Analysis

                                      Stool Analysis