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INTRODUCTION OF TUMOR MARKERS

 INTRODUCTION OF TUMOR MARKERS 

Cancer is a word used to describe a condition characterized by spreading destruction of any kind 
Cancer is the name given to a group or diseases associated with the development , growth  , and spread of destructive overgrowth of tissue , called Malignant tumor or neoplasm , in living organism 


A tumor is benign when it is restricted to its primary site and malignant when it is capable of invading surrounding tissue.

Malignant Tumors 

these are invasive , destruction and associated with a generally poor prognosis and high mortality rate 
Malignant tumors growth may occur at any site in the organism and may spread in time to other sites . 

Pathogenesis of the disease is largely due to 

a- Obstruction and destruction of other vital structures in the body 
b - Functional activity of a substance produced by the tumor .
c - Bleeding 
d - Infection 
e - Toxic substances associated with infarction and necrosis 

The  major difference between normal cells and tumor cells is that growth control has been lost in tumor cells . 

Neoplastic transformation is associated with altered gene expression , which may affect production of enzymes  , hormones , receptors , protein and metabolites that are released into the circulatory system .
These substances , if they can be measured and in the diagnosis and characterization of disease and have potential use in the treatments and cure of cancers . 
This group of substances has come to be known as Tumor markers .










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