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Iron deficiency Anemia

Iron deficiency Anemia 

Causes - Clinical and laboratory findings


Causes 
Iron deficiency  due to reduced dietary intake such as animal- 
- Chronic blood loss due to  : 
- Bleeding Ulcers 
- Tumor of the gastrointestinal or Urinary tract 
 - Heavy infestation  with blood sucking external parasites such as lice , fleas 
- Menorrhea in Primates 
- Reduced  iron absorption  caused by malabsorption

Clinical and laboratory findings 


1 - Complete blood count (CBC)

- RBCs are microcytic hypochromic anemia 
- Hb concentration , RBCs count and PCV are reduced 

2- Blood film

shows microcytic , hypochromic red blood cells, anisocytosis and poikilocytosis 

3- Esinophilia 

occurs with parasitic infestations 

4- Secondary  thrombocytosis 
5- Reticulocyte count is normal 
6- Iron profile : Serum iron , serum ferritin , iron% saturation are reduced but total iron binding capacity (TIBC) is increased 
7- Bone marrow Hypercellular  with erythroid  hyperplasia and reduced M/E ratio (myeloid/erythro) ratio 


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