Iron deficiency Anemia

Causes - Clinical and laboratory findings

Causes

Iron deficiency due to reduced dietary intake such as animal-

- Chronic blood loss due to :

- Bleeding Ulcers

- Tumor of the gastrointestinal or Urinary tract

- Heavy infestation with blood sucking external parasites such as lice , fleas

- Menorrhea in Primates

- Reduced iron absorption caused by malabsorption

Clinical and laboratory findings

1 - Complete blood count (CBC)

- RBCs are microcytic hypochromic anemia

- Hb concentration , RBCs count and PCV are reduced

2- Blood film

shows microcytic , hypochromic red blood cells, anisocytosis and poikilocytosis

3- Esinophilia

occurs with parasitic infestations

4- Secondary thrombocytosis

5- Reticulocyte count is normal

6- Iron profile : Serum iron , serum ferritin , iron% saturation are reduced but total iron binding capacity (TIBC) is increased

7- Bone marrow Hypercellular with erythroid hyperplasia and reduced M/E ratio (myeloid/erythro) ratio

Comments

MICROSCOPIC URINALYSIS Methodology A sample of well-mixed urine (usually 10-15 ml) is centrifuged in a test tube at relatively low speed (about 2-3,000 rpm) for 5-10 minutes until a moderately cohesive button is produced at the bottom of the tube. The supernatant is decanted and a volume of 0.2 to 0.5 ml is left inside the tube. The sediment is resuspended in the remaining supernatant by flicking the bottom of the tube several times. A drop of resuspended sediment is poured onto a glass slide and coverslipped.

Liver Enzymes

Liver Enzymes Definition A liver enzyme is a protein that helps to speed up a chemical reaction in the liver. Liver function tests are blood tests that are used to evaluate various functions of the liver - for example, metabolism, storage, filtration and excretion, which are often performed by liver enzymes. However, not all liver function tests are measures of enzyme function. • ALT - (alanine aminotransferase ) - was previously called SGPT is more specific for liver damage. The ALT is an enzyme that is produced in the liver cells (hepatocytes) therefore it is more specific for liver disease than some of the other enzymes. It is generally increased in situations where there is damage to the liver cell membranes. All types of liver inflammation can cause raised ALT. • AST - (aspartate aminotransferase) which was previously called SGOT. This is a mitochondrial enzyme that is also present in heart, muscle, kidney and brain therefore it is less specific

Interpretation Of Lab Results

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