Total cholesterol

table of contents
  1. Specimen : Serum (1 ml ) 
  2.  
  3. Reference value : Desirable less than 200 mg/dL
  4.                              Borderline 200 - 239 mg/dL 
  5.                               High Greater Than 240 mg/dL 
  6.  
  7. Method : Spectrophotometer 
  8.  
  9. Description :
  10.  Cholesterol is a lipid needed to from cell membranes and a component of the materials that render the skin waterproof . It also helps form bile salts , adrenal corticosteroids , estrogen and androgen .
  11.  
  12. Cholesterol is obtained from the diet (exogenous cholesterol ) and also synthesized in the body( endogenous cholesterol ) . Although most body cells can form som cholesterol , it is produced mainly by liver and intestinal mucosa . 
  13. Very low cholesterol value , as is sometimes seen in critically ill patients , can be as life threatening as very high levels . 
  14.  
  15. Indications 
  16.  
  17. - Assist in determination risk of cardiovascular disease 
  18. - Assist in diagnosis of nephritic syndrome , hepatic disease , pancreatitis  , and thyroid disorders . 
  19. - Evaluate the response to dietary and drug therapy for hypercholesterolemia
  20. -Investigate hypercholesterolemia in light of family history of cardiovascular disease 
  21. Read more :Normal Regulation of Blood Glucose and The important roles of insulin and glucagon
  22. Interpretation
  23. Increased in 
  24. Read more :Blood Glucose
  25. 1 -  Primary hypercholesterolemia 
  26.  
  27. - Congenital lipoprotein lipase deficiency 
  28. - Hypercholesterolemia 
  29. - Familial hyperlipoproteinemia 
  30.  
  31. 2 - Secondary  hypercholesterolemia 
  32.  
  33. - Cholestasis 
  34. - Chronic renal failure , Nephrotic  syndrome 
  35. - Diabetes ( with poor control ) due to decrease activity pf lipoprotein lipase ( as insulin is reduced ) and lipolysis is increased
  36. - Diets high in cholesterol and fats .
  37. - Glycogen storage disease ( Von Gierke disease ) 
  38. - Hepatic lipidosis ( alcoholism ) .
  39. - Hyperthyroidism due to decrease cholesterol utilization and reduce activity of lipoprotein lipase . 
  40. - Ischemic heart disease 
  41. - Obesity 
  42. - Acute pancreatic necrosis 
  43. - Pregnancy 
  44. Decreased in : 
  45. - Chronic myelocytic leukemia , Polycythemia 
  46. - Hyperthyroidism 
  47. - Liver disease ( Sever ) 
  48. - Malabsorpion  and malnutrition syndromes , sever illness . 
  49. - pernicious anemia , Sideroblastic anemia 
  50. - Thalassemia . 
  51. Read more :Can Cortisone Trigger Diabetes? Understanding Its Effects on the Pancreas and Glucose Levels


Specimen : Serum (1 ml ) 

 

Reference value : Desirable less than 200 mg/dL

                             Borderline 200 - 239 mg/dL 

                              High Greater Than 240 mg/dL 

 

Method : Spectrophotometer 

 

Description :

 Cholesterol is a lipid needed to from cell membranes and a component of the materials that render the skin waterproof . It also helps form bile salts , adrenal corticosteroids , estrogen and androgen .

 

Cholesterol is obtained from the diet (exogenous cholesterol ) and also synthesized in the body( endogenous cholesterol ) . Although most body cells can form som cholesterol , it is produced mainly by liver and intestinal mucosa . 

Very low cholesterol value , as is sometimes seen in critically ill patients , can be as life threatening as very high levels . 

 

Indications 

 

- Assist in determination risk of cardiovascular disease 

- Assist in diagnosis of nephritic syndrome , hepatic disease , pancreatitis  , and thyroid disorders . 

- Evaluate the response to dietary and drug therapy for hypercholesterolemia

-Investigate hypercholesterolemia in light of family history of cardiovascular disease 



Interpretation


Increased in 


Read more :Blood Glucose

1 -  Primary hypercholesterolemia 

 

- Congenital lipoprotein lipase deficiency 

- Hypercholesterolemia 

- Familial hyperlipoproteinemia 

 

2 - Secondary  hypercholesterolemia 

 

- Cholestasis 

- Chronic renal failure , Nephrotic  syndrome 

- Diabetes ( with poor control ) due to decrease activity pf lipoprotein lipase ( as insulin is reduced ) and lipolysis is increased

- Diets high in cholesterol and fats .

- Glycogen storage disease ( Von Gierke disease ) 

- Hepatic lipidosis ( alcoholism ) .

- Hyperthyroidism due to decrease cholesterol utilization and reduce activity of lipoprotein lipase . 

- Ischemic heart disease 

- Obesity 

- Acute pancreatic necrosis 

- Pregnancy 


Decreased in


- Chronic myelocytic leukemia , Polycythemia 

- Hyperthyroidism 

- Liver disease ( Sever ) 

- Malabsorpion  and malnutrition syndromes , sever illness . 

- pernicious anemia , Sideroblastic anemia 

- Thalassemia . 






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