table of contents
- Specimen : Serum (1 ml )
- Reference value : Desirable less than 200 mg/dL
- Borderline 200 - 239 mg/dL
- High Greater Than 240 mg/dL
- Method : Spectrophotometer
- Description :
- Cholesterol is a lipid needed to from cell membranes and a component of the materials that render the skin waterproof . It also helps form bile salts , adrenal corticosteroids , estrogen and androgen .
- Cholesterol is obtained from the diet (exogenous cholesterol ) and also synthesized in the body( endogenous cholesterol ) . Although most body cells can form som cholesterol , it is produced mainly by liver and intestinal mucosa .
- Very low cholesterol value , as is sometimes seen in critically ill patients , can be as life threatening as very high levels .
- Indications
- - Assist in determination risk of cardiovascular disease
- - Assist in diagnosis of nephritic syndrome , hepatic disease , pancreatitis , and thyroid disorders .
- - Evaluate the response to dietary and drug therapy for hypercholesterolemia
- -Investigate hypercholesterolemia in light of family history of cardiovascular disease
- Read more :Normal Regulation of Blood Glucose and The important roles of insulin and glucagon
- Interpretation
- Increased in
- Read more :Blood Glucose
- 1 - Primary hypercholesterolemia
- - Congenital lipoprotein lipase deficiency
- - Hypercholesterolemia
- - Familial hyperlipoproteinemia
- 2 - Secondary hypercholesterolemia
- - Cholestasis
- - Chronic renal failure , Nephrotic syndrome
- - Diabetes ( with poor control ) due to decrease activity pf lipoprotein lipase ( as insulin is reduced ) and lipolysis is increased
- - Diets high in cholesterol and fats .
- - Glycogen storage disease ( Von Gierke disease )
- - Hepatic lipidosis ( alcoholism ) .
- - Hyperthyroidism due to decrease cholesterol utilization and reduce activity of lipoprotein lipase .
- - Ischemic heart disease
- - Obesity
- - Acute pancreatic necrosis
- - Pregnancy
- Decreased in :
- - Chronic myelocytic leukemia , Polycythemia
- - Hyperthyroidism
- - Liver disease ( Sever )
- - Malabsorpion and malnutrition syndromes , sever illness .
- - pernicious anemia , Sideroblastic anemia
- - Thalassemia .
- Read more :Can Cortisone Trigger Diabetes? Understanding Its Effects on the Pancreas and Glucose Levels