alpha1 -Lipoprotein cholesterol ,high density cholesterol , HDLC , B- Lipoprotein cholesterol , low- density cholesterol , LDLC .
Specimen : Serum (2 ml )
Reference value : HDL 40 - 65 mg/dL
LDL 80 - 185 mg/dL
Method : Spectrophotometer
Description
High - density lipoprotein cholesterol (HDLC) and Low- density lipoprotein cholesterol (LDLC)
are the major transport proteins for cholesterol in the body . It is believed that HDLC may have protective properties in that its role includes transporting cholesterol from the arteries to the liver . LDLC is the major transport protein for cholesterol to the arteries from the liver .
LDLC can be calculated using to total cholesterol , total triglycerides , and HDLC levels.
HDLC levels less than 40 mg/ dL in men and women represnte a coronary risk factor . There is an inverse relationship between HDLC and risk of coronary artery disease (CAD ) ( i.e lower HDLC levels represent a higher risk of CAD . Levels of LDLC un terms of risk for CAD are directly proportional to risk and vary by age group .
The LDLC can be estimated using the following friedewald formula :
LDLC = Total cholesterol - HDLC - VLDLC .
Very-low-density lipoprotein in cholesterol (VLDLC) is estimated by dividing the triglycerides conventional unites by 5 .
It is important to note that the formula is valid only if triglycerides are less than 400 mg/ dl
Indication
- Determine the risk of cardiovascular disease .
- Evaluate the response to dietary and drug therapy for hypercholesterolemia
