table of contents
- Synonyms :
- alpha1 -Lipoprotein cholesterol ,high density cholesterol , HDLC , B- Lipoprotein cholesterol , low- density cholesterol , LDLC .
- Specimen : Serum (2 ml )
- Reference value : HDL 40 - 65 mg/dL
- LDL 80 - 185 mg/dL
- Method : Spectrophotometer
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- Description
- High - density lipoprotein cholesterol (HDLC) and Low- density lipoprotein cholesterol (LDLC)
- are the major transport proteins for cholesterol in the body . It is believed that HDLC may have protective properties in that its role includes transporting cholesterol from the arteries to the liver . LDLC is the major transport protein for cholesterol to the arteries from the liver .
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- LDLC can be calculated using to total cholesterol , total triglycerides , and HDLC levels.
- HDLC levels less than 40 mg/ dL in men and women represnte a coronary risk factor . There is an inverse relationship between HDLC and risk of coronary artery disease (CAD ) ( i.e lower HDLC levels represent a higher risk of CAD . Levels of LDLC un terms of risk for CAD are directly proportional to risk and vary by age group .
- The LDLC can be estimated using the following friedewald formula :
- LDLC = Total cholesterol - HDLC - VLDLC .
- Very-low-density lipoprotein in cholesterol (VLDLC) is estimated by dividing the triglycerides conventional unites by 5 .
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- It is important to note that the formula is valid only if triglycerides are less than 400 mg/ dl
- Indication
- - Determine the risk of cardiovascular disease .
- - Evaluate the response to dietary and drug therapy for hypercholesterolemia
- - Investigation hereditary hypercholesterolemia
- Interpretation
- HDLC increased in :
- - Exercise
- - Familial hyper-lipoproteininemia
- - Alcoholism
- - Biliary cirrhosis
- - Chronic hepatitis
- HDLC decreased in
- - Hypo- Lipoproteininemia
- - Hyper-triglyceridemia ( all cause )
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- LDLC increased in
- - Hyperlipoproteinemia
- - Chronic renal failure
- - Cushing's syndrome
- - Diabetes
- - Diet high in cholesterol and saturated fat
- - Hepatic disease
- - Hepatic obstruction
- - Hypothyroidism
- - Nephrotic syndrome
- - Pregnancy
- LDLC decreased in
- - Hyperlipopoteinemia
- - Acute stress ( Sever burns , illness )
- - Chronic anemias
- - Sever hepatocellular destruction or disease .
- - Inflammatory joint disease .