few months agoStool Analysis: A Comprehensive Guide to Digestive Health and Disease Detection

table of contents

2. Macrocytic achylic anemia 
3.  
4. ( Congenital pernicious anemia - Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) -
5. Complications 
6. Definition  - Causes, incidence, and risk factors - Symptoms -  Signs and tests  -  Treatment - Expectations (prognosis)  - Complications  - Calling your health care provider  -  Prevention 
7.  
8. Definition    
9. Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells. Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia)
10. Pernicious anemia is a type of megaloblastic anemia
11.  
12.  
13. Causes, incidence, and risk factors   
14.  
15. Intrinsic factor is a protein the body uses to absorb vitamin B12. When gastric secretions do not have enough intrinsic factor, vitamin B12 is not adequately absorbed, resulting in pernicious anemia and other problems related to low levels of vitamin B12.
16. Because vitamin B12 is needed by nerve cells and blood cells for them to function properly, deficiency can cause a wide variety of symptoms, including fatigue, shortness of breath, tingling sensations, difficulty walking, and diarrhea.
17. Other causes of low levels of intrinsic factor (and thus of pernicious anemia) include atrophic gastric mucosa, autoimmunity against gastric parietal cells, and autoimmunity against intrinsic factor.
18. Absence of intrinsic factor itself is the most common cause of vitamin B12 deficiency. Intrinsic factor is produced by cells within the stomach. In adults, the inability to make intrinsic factor can be the result of chronic gastritis or the result of surgery to remove the stomach. The onset of the disease is slow and may span decades.
19. Very rarely, infants and children are found to have been born lacking the ability to produce effective intrinsic factor. This form of congenital pernicious anemia is inherited as an autosomal recessive disorder. (You need a defective gene from both parents to get it.) However, most often, pernicious anemia and other forms of megaloblastic anemia in children results from other causes of vitamin B12 deficiency or other vitamin deficiencies.
20. Although a juvenile form of the disease can occur in children, pernicious anemia usually does not appear before the age of 30. The average age at diagnosis is 60 years. In fact, one recent study revealed that nearly 2 percent of individuals over 60 years old suffer from pernicious anemia. Furthermore, slightly more women than men are affected. The disease can affect all racial groups, but occurs more often among people of Scandinavian or Northern European descent.
21. Risk factors include a family history of pernicious anemia, Scandinavian or Northern European descent, and a history of autoimmune endocrine disorders. Pernicious anemia is seen in association with some autoimmune endocrine diseases such as type 1 diabetes, hypoparathyroidism, Addison's disease, hypopituitarism, testicular dysfunction, Graves disease, chronic thyroiditis, myasthenia gravis, secondary amenorrhea and vitiligo.
22. In addition to pernicious anemia, other causes of vitamin B12 Deficiency include:
24. Nutrition (strict vegetarians without B12 supplementation, poor diet in infant, or poor maternal nutrition during pregnancy)
25. Infection (intestinal parasites, bacterial overgrowth)
26. Gastrointestinal disease (stomach removal surgery, celiac disease (sprue), Crohn's disease)
27. Drugs (colchicine, neomycin, tuberculosis treatment with para amino salicylic acid)
28. Metabolic disorders (methylmalonic aciduria, homocystinuria) 
33.  
34. Symptoms  
35.   
36. Many cells in our body need vitamin B12, including nerve cells and blood cells. Inadequate vitamin B12 gradually affects sensory and motor nerves, causing neurological problems to develop over time. It is important to know that the neurological effects of vitamin B12 deficiency may be seen before anemia is diagnosed.
37. The anemia also affects the gastrointestinal system and the cardiovascular system. The following symptoms may indicate pernicious anemia:
38. shortness of breath
39. fatigue
40. pallor
41. rapid heart rate
42. loss of appetite
43. diarrhea
44. tingling and numbness of hands and feet
45. sore mouth
46. unsteady gait, especially in the dark
47. tongue problems
48. smell, impaired
49. gums, bleeding
50. positive Babinski's reflex
51. loss of deep tendon reflexes
52. personality changes, ( megaloblastic madness)
55.  
56.  Signs and tests   
57.  
58. Tests that may indicate pernicious anemia include:
59.  
61. CBC results that show low hematocrit and hemoglobin with elevated MCV (low red blood cell count with large-sized red blood cells) 2 - CBC showing low white blood count and low platelets 3 - low reticulocyte count Read more :Anemia - idiopathic aplastic 4 - bone marrow examination (only needed if diagnosis is unclear) serum LDH 5 - below normal serum vitamin B-12 level 6 - Schilling test Read more :G-6-PD deficiency 7 - measurement of serum holotranscobalamin II 8 - measurment of methylmalonic acid (MMA) 
65.  
66. This disease may also alter the results of the following tests:
67.   - TIBC
68.   - peripheral smear Read more :Hemolytic anemia - leukocyte alkaline phosphatase - gastrin Read more :Red blood cells ( sickle cell, elliptocytosis , spherocytosis , multiple sickle cells , Ovalocytoses , sickle and pappenheimer , target cells ) - cholesterol test
69.  - bilirubin
70.  
71. Treatment   
72.  
73. Monthly vitamin B12 injections are the definitive treatment to correct the vitamin B12 deficiency. This therapy corrects the anemia and may correct the neurological complications if given soon enough. Since about 1% of vitamin B12 is absorbed (even in the absence of intrinsic factor), some doctors recommend that elderly patients with gastric atrophy take oral vitamin B12 supplements in addition to monthly injections.
74. There is also a preparation of vitamin B12 that may be given intranasally (in the nose). A well-balanced diet is essential to provide other elements such as folic acid, iron, and vitamin C for healthy blood cell development.
75.  
79. Expectations (prognosis)    
80.  
81. The outcome is usually excellent with treatment.
82.  
86. Complications   
87.  
88. People with pernicious anemia may have gastric polyps and have twice the incidence of gastric cancer and gastric carcinoid tumors than the normal population.
89. Persistent neurological defects may be present if treatment is delayed.
90. Vitamin B12 deficiency affects the appearance of all epithelial cells, therefore an untreated woman may obtain a false positive pap smear. 
91.  
93. Calling your health care provider    
94.  
95. Call your health care provider if symptoms suggestive of vitamin B12 deficiency develop.
96.  
98. Prevention    
99.  
100. Pernicious anemia is not preventable, but with early detection and treatment of vitamin B12 deficiency, complications are readily controlled.
101.  

Macrocytic achylic anemia 

 

( Congenital pernicious anemia - Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) -

Complications 

Definition  - Causes, incidence, and risk factors - Symptoms -  Signs and tests  -  Treatment - Expectations (prognosis)  - Complications  - Calling your health care provider  -  Prevention 

 

Definition    

Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells. Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia)

Pernicious anemia is a type of megaloblastic anemia

 

 

Causes, incidence, and risk factors   

 

Intrinsic factor is a protein the body uses to absorb vitamin B12. When gastric secretions do not have enough intrinsic factor, vitamin B12 is not adequately absorbed, resulting in pernicious anemia and other problems related to low levels of vitamin B12.

Because vitamin B12 is needed by nerve cells and blood cells for them to function properly, deficiency can cause a wide variety of symptoms, including fatigue, shortness of breath, tingling sensations, difficulty walking, and diarrhea.

Other causes of low levels of intrinsic factor (and thus of pernicious anemia) include atrophic gastric mucosa, autoimmunity against gastric parietal cells, and autoimmunity against intrinsic factor.

Absence of intrinsic factor itself is the most common cause of vitamin B12 deficiency. Intrinsic factor is produced by cells within the stomach. In adults, the inability to make intrinsic factor can be the result of chronic gastritis or the result of surgery to remove the stomach. The onset of the disease is slow and may span decades.

Very rarely, infants and children are found to have been born lacking the ability to produce effective intrinsic factor. This form of congenital pernicious anemia is inherited as an autosomal recessive disorder. (You need a defective gene from both parents to get it.) However, most often, pernicious anemia and other forms of megaloblastic anemia in children results from other causes of vitamin B12 deficiency or other vitamin deficiencies.

Although a juvenile form of the disease can occur in children, pernicious anemia usually does not appear before the age of 30. The average age at diagnosis is 60 years. In fact, one recent study revealed that nearly 2 percent of individuals over 60 years old suffer from pernicious anemia. Furthermore, slightly more women than men are affected. The disease can affect all racial groups, but occurs more often among people of Scandinavian or Northern European descent.

Risk factors include a family history of pernicious anemia, Scandinavian or Northern European descent, and a history of autoimmune endocrine disorders. Pernicious anemia is seen in association with some autoimmune endocrine diseases such as type 1 diabetes, hypoparathyroidism, Addison's disease, hypopituitarism, testicular dysfunction, Graves disease, chronic thyroiditis, myasthenia gravis, secondary amenorrhea and vitiligo.

In addition to pernicious anemia, other causes of vitamin B12 Deficiency include:

• Nutrition (strict vegetarians without B12 supplementation, poor diet in infant, or poor maternal nutrition during pregnancy)

• Infection (intestinal parasites, bacterial overgrowth)

• Gastrointestinal disease (stomach removal surgery, celiac disease (sprue), Crohn's disease)

• Drugs (colchicine, neomycin, tuberculosis treatment with para amino salicylic acid)

• Metabolic disorders (methylmalonic aciduria, homocystinuria) 

 

Symptoms  

  

Many cells in our body need vitamin B12, including nerve cells and blood cells. Inadequate vitamin B12 gradually affects sensory and motor nerves, causing neurological problems to develop over time. It is important to know that the neurological effects of vitamin B12 deficiency may be seen before anemia is diagnosed.

The anemia also affects the gastrointestinal system and the cardiovascular system. The following symptoms may indicate pernicious anemia:

• shortness of breath

• fatigue

• pallor

• rapid heart rate

• loss of appetite

• diarrhea

• tingling and numbness of hands and feet

• sore mouth

• unsteady gait, especially in the dark

• tongue problems

• smell, impaired

• gums, bleeding

• positive Babinski's reflex

• loss of deep tendon reflexes

• personality changes, ( megaloblastic madness)

 

 Signs and tests   

 

Tests that may indicate pernicious anemia include:

 

CBC results that show low hematocrit and hemoglobin with elevated MCV (low red blood cell count with large-sized red blood cells)
2 - CBC showing low white blood count and low platelets
3 - low reticulocyte count

Read more :Anemia - idiopathic aplastic

4 - bone marrow examination (only needed if diagnosis is unclear)
serum LDH
5 - below normal serum vitamin B-12 level
6 - Schilling test

Read more :G-6-PD deficiency

7 - measurement of serum holotranscobalamin II
8 - measurment of methylmalonic acid (MMA) 

 

This disease may also alter the results of the following tests:

 

- TIBC

 
- peripheral smear

Read more :Hemolytic anemia

- leukocyte alkaline phosphatase

- gastrin

Read more :Red blood cells ( sickle cell, elliptocytosis , spherocytosis , multiple sickle cells , Ovalocytoses , sickle and pappenheimer , target cells )

- cholesterol test

 - bilirubin

 

Treatment   

 

Monthly vitamin B12 injections are the definitive treatment to correct the vitamin B12 deficiency. This therapy corrects the anemia and may correct the neurological complications if given soon enough. Since about 1% of vitamin B12 is absorbed (even in the absence of intrinsic factor), some doctors recommend that elderly patients with gastric atrophy take oral vitamin B12 supplements in addition to monthly injections.

There is also a preparation of vitamin B12 that may be given intranasally (in the nose). A well-balanced diet is essential to provide other elements such as folic acid, iron, and vitamin C for healthy blood cell development.

 

Expectations (prognosis)    

 

The outcome is usually excellent with treatment.

 

Complications   

 

• People with pernicious anemia may have gastric polyps and have twice the incidence of gastric cancer and gastric carcinoid tumors than the normal population.

• Persistent neurological defects may be present if treatment is delayed.

• Vitamin B12 deficiency affects the appearance of all epithelial cells, therefore an untreated woman may obtain a false positive pap smear. 

 

Calling your health care provider    

 

Call your health care provider if symptoms suggestive of vitamin B12 deficiency develop.

 

Prevention    

 

Pernicious anemia is not preventable, but with early detection and treatment of vitamin B12 deficiency, complications are readily controlled.

 

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