Skip to main content

A : G Ratio

A : G Ratio 

- Most automated chemistry analyzers measure albumin and total serum protein . Globulins are determined by subtraction . 
- A : G ratio = albumin divided by globulin 
- Alterations in A : G  ratio suggest unequal loss or over production of protein fractions 
- The A / G ratio is useful in the evaluation of liver and kidney disease . A / G ratio less than 1.0 is clinically significant 

- Increases in A : G ratio observed in case of decreased globulins ( hypogammaglobulinemia ) - decreases in total protein 

- Decreases in A : G ratio observed in case of decreased albumin ( hypoalbuminemia ) or increased globulin ( hypergammaglobulinemia ) .

Comments

Post a Comment

Popular posts from this blog

MICROSCOPIC URINALYSIS

MICROSCOPIC URINALYSIS   Methodology A sample of well-mixed   urine (usually 10-15 ml) is centrifuged in a test tube at relatively low speed (about 2-3,000 rpm) for 5-10 minutes until a moderately cohesive button is produced at the bottom of the tube. The supernatant is decanted and a volume of 0.2 to 0.5 ml is left inside the tube. The sediment is resuspended in the remaining supernatant by flicking the bottom of the tube several times. A drop of resuspended sediment is poured onto a glass slide and coverslipped.
1 comment
Read more

Liver Enzymes

Liver Enzymes   Definition A liver enzyme is a protein that helps to speed up a chemical reaction in the   liver. Liver function tests are blood tests that are used to evaluate various functions of the liver - for example, metabolism, storage, filtration and excretion, which are often performed by liver enzymes. However, not all liver function tests are measures of enzyme function. • ALT - (alanine aminotransferase )   - was previously called SGPT is more specific for liver damage. The ALT is an enzyme that is produced in the liver cells (hepatocytes) therefore it is more specific for liver disease than some of the other enzymes. It is generally increased in situations where there is damage to the liver cell membranes. All types of liver inflammation can cause raised ALT.    • AST - (aspartate aminotransferase) which was previously called SGOT. This is a mitochondrial enzyme that is also present in heart, muscle, kidney and brain ...
3 comments
Read more

Gamma globulins

Gamma globulins   Increased in immunoglobulins are often referred to as hyper gammaglobulinemia or gammopathies  Hypogammaglobulinemia This most often results from  decreased synthesis , but could also be associated with increased loss .  1 - Decreased synthesis ( High A : G ratio )  a- failure of passive transfer or colostrum deprivation  b - Combined immunodeficiency disease ( Both T & B cells are deficient )  c - Agammaglobulinemia  d - Acquired deficiency associated with inflammation , immunosuppressive drugs or neoplasia 
Post a Comment
Read more