IRON
Synonym - specimen - Refrence Value - Method - Description - Indications
Synonym : Fe
Specimen : Serum
Reference Value : 65 - 175 ug/d
Method : Spectrophotometry
Description
Iron plays a principle role in erythropoiesis
Irone is necessary for the proliferation and maturation of red blood cells and is required for hemoglobin synthesis .65 perecent of iron resides in hemoglobin and 3 percent in myoglobin .a small amount is also found in cellular enzymes that catalyze the oxidation and reduction of iron . The remainder of iron is stored in the liver , bone marrow , and spleen as ferritin or hemosiderin .Any iron present in the serum is in transit among the alimentary tract , the bone marrow , and available iron storage forms . Iron travels in blood stream bound to transferrin , a protein manufactured by the liver . Normally iron enters the body by oral ingestion , only 10% is absorbed , but 20% can be absorbed in patients with iron deficiency anemia . unbound iron is highly toxic
Indications
1 - Assists in diagnostic of blood loss , indicated by decreased serum iron
2 - Assists in the diagnostic of hemochromatosis or other disorders of iron metabolism and storage
3 - Determine the presence of disorders that involved defects in iron absorption
4 - Determine the differential diagnosis of anemia
5 - Evaluate accidental iron poisoning
6 - Evaluate thalassemia and sideroblastic anemia
7 - Monitor hematologic responses during pregnancy
8 - Monitor response to treatment for anemia
Interpretation
Iron Increased in
1 - Acute iron poisoning (childern)x
2 - Acute liver disease
3 - Aplastic anemia
4 - Excessive iron therapy
5 - Hemochromatosis
6 - Hemolytic anemias
7 - Lead toxicity
8 - pernicious anemia
9 - Sideroblastic anemia
10 - Thalassemia
11 - Drugs : estrogen , oral contraceptives
Iron Decreased in
1 - Acute and chronic infection
2 - Carcinoma
3 - Chronic blood loss
4 - Hypothyroidism
5 - Iron-deficiency anemia
6 - Chronic renal failure
7 - postoperative states
8 - Active hematopoiesis
9 - Protein malnutrition